Oncofertility for gynecologic and non-gynecologic cancers: Fertility sparing in young women of reproductive age

Dursun P., DOĞAN N. U., Ayhan A.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, vol.92, no.3, pp.258-267, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 92 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1016/j.critrevonc.2014.07.001
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.258-267
  • Keywords: Fertility preservation, Cancer, Oncofertility, Gynecologic cancers, Cervical cancer, Endometrial cancer, Ovarian cancer, TOTAL-BODY IRRADIATION, OVARIAN TISSUE, BREAST-CANCER, UTERUS TRANSPLANTATION, HORMONE AGONIST, FEMALE-PATIENTS, PRESERVATION, STIMULATION, CRYOPRESERVATION, FROZEN
  • Akdeniz University Affiliated: Yes


About ten percent of all female cancer survivors is younger than 40 years of age. For these young women the primary goal is to ensure the highest possibility of cure and to maintain the reproductive functions as well. Oncofertility is a new concept including both oncology and reproductive medicine. By this recently defined concept young women will have maximal chance to make an optimal decision without any significant impact and delay in oncologic outcome. Oncofertility concept could be applied for genital cancer as well as non-genital cancer of reproductive age. Currently sperm and embryo banking are the standard methods used for young patients with cancer whose future fertility is under risk. In contrary oocyte banking, ovarian tissue cryopreservation are all controversial procedures and still accepted as experimental by many authors although American Society of Reproductive Medicine (ASRM) consideres oocyte cryopreservation "no longer experimental". For genital cancers procedures for oncofertility depends on the type of the cancer and the treatment of choice. In this review the current data and concepts regarding oncofertility concept including the gynecologic oncologic perspective is reviewed. (C) 2014 Elsevier Ireland Ltd. All rights reserved.