The effect of melatonin on digoxin-induced cardiac damage in cardiomyocytes
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.120, no.1, pp.78-85, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 120 Issue: 1
- Publication Date: 2019
- Doi Number: 10.4149/bll_2019_012
- Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.78-85
- Keywords: digoxin, oxidative stress, cardiomyocyte, INDUCED OXIDATIVE STRESS, DORSAL-ROOT GANGLION, CYTOCHROME-C, CALCIUM OVERLOAD, TRPV1 CHANNELS, APOPTOSIS, RECEPTOR, TRANSIENT, ACTIVATION, TRPM2
- Open Archive Collection: AVESIS Open Access Collection
- Akdeniz University Affiliated: Yes
Abstract
OBJECTIVES: Digoxin is a cardiac glycoside which is widely used in cardiovascular medicine. Oxidative stress, as well as intracellular Ca2+ overload, plays an important role in digoxin toxicity. Transient receptor potential vanilloid 1 (TRPV1) channels are found in cardiomyocyte cells and they are activated by reactive oxygen species. We investigated the effects of digoxin toxicity and alterations in Ca2+ influx, oxidative stress and apoptosis through TRPV1 channels and modulator role of melatonin in cardiomyocytes.