The effect of melatonin on digoxin-induced cardiac damage in cardiomyocytes

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Ovey I. S., Oncel C. R.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.120, sa.1, ss.78-85, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4149/bll_2019_012
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.78-85
  • Anahtar Kelimeler: digoxin, oxidative stress, cardiomyocyte, INDUCED OXIDATIVE STRESS, DORSAL-ROOT GANGLION, CYTOCHROME-C, CALCIUM OVERLOAD, TRPV1 CHANNELS, APOPTOSIS, RECEPTOR, TRANSIENT, ACTIVATION, TRPM2
  • Akdeniz Üniversitesi Adresli: Evet

Özet

OBJECTIVES: Digoxin is a cardiac glycoside which is widely used in cardiovascular medicine. Oxidative stress, as well as intracellular Ca2+ overload, plays an important role in digoxin toxicity. Transient receptor potential vanilloid 1 (TRPV1) channels are found in cardiomyocyte cells and they are activated by reactive oxygen species. We investigated the effects of digoxin toxicity and alterations in Ca2+ influx, oxidative stress and apoptosis through TRPV1 channels and modulator role of melatonin in cardiomyocytes.