Dehydroepiandrosterone supplementation attenuates ovarian ageing in a galactose-induced primary ovarian insufficiency rat model

Sözen B., Ozekinci M., ERMAN M., GUNDUZ T., DEMİR N., AKOURI R.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol.36, no.10, pp.2181-2189, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.1007/s10815-019-01560-4
  • Journal Name: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2181-2189
  • Keywords: Rat, Galactosemia, Primary ovarian insufficiency, DHEA, FOLLICLE-STIMULATING-HORMONE, GROWTH-FACTOR-I, ANDROGEN RECEPTOR, FAILURE, EXPRESSION, WOMEN, OOCYTE, ACTIVATION, NUMBER, MICE
  • Akdeniz University Affiliated: Yes

Abstract

Purpose Almost every female classic galactosemia patient develops primary ovarian insufficiency (POI). The unique pathophysiology of classic galactosemia, with a severely reduced follicle pool at an early age, requires a new therapeutic approach. This study evaluated the effect of dehydroepiandrosterone (DHEA) on ovarian tissue in a galactose-induced POI rat model.