The Presence of Kinesin Superfamily Motor Proteins KIFC1 and KIF17 in Normal and Pathological Human Placenta

Sati L., Seval-Celik Y., Unek G., KORGUN E. T., Demir R.

PLACENTA, cilt.30, sa.10, ss.848-854, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 10
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.placenta.2009.07.005
  • Dergi Adı: PLACENTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.848-854
  • Anahtar Kelimeler: Human placenta, KIFC1, KIF17, Preeclampsia, Diabetes, Placental transport, MALE GERM-CELLS, VESICLE TRANSPORT, BINDING-PROTEIN, GENE, MOUSE, TRANSCRIPTION, EXPRESSION, SPERMATOGENESIS, VASCULOGENESIS, ANGIOGENESIS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Kinesin superfamily proteins (KIFs) are motor proteins that participate in chromosomal and spindle movements during mitosis and meiosis, and transport membranous organelles and macromolecules fundamental for cellular functions. Although the roles of KIFs in axonal and dendritic transports have been studied extensively, their role in intracellular transport in general is less well known. The diversity of kinesins suggests that each kinesin may have a specific function. Therefore, in this study we aimed to investigate the presence and cellular localization of KIFC1 and KIF17 in normal and pathological human placentas. First-trimester (22-56 days) and normal, preeclamptic (PE), and diabetic-term placental tissues were obtained and further studied by immunohistochemistry (IHC) and Western blot methods.