Akademik Veri Yönetim Sistemi
THE MALAYSIAN JOURNAL OF PATHOLOGY, cilt.44, sa.3, ss.461-467, 2022 (SCI-Expanded)
Introduction and Objectives: Prostate cancer is one of the most commonly diagnosed cancers in
American men. Apelin is an endogenous peptide identified as the ligand of the G protein-associated
apelin receptor. Apelin and apelin receptor have many tissues distribution and they participate in
pathological processes, such as cancer. Apelin stimulates cancer angiogenesis. However, there are
insufficient data in the literature regarding the role of apelin/apelin receptor in normal tissue, highgrade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma tissues. Therefore, this study
aimed to investigate the apelin and apelin receptor expression levels in tissues of normal prostate
tissue, high-grade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. Materials and
Methods: In this study, 38 samples of patients undergoing radical prostatectomy were used. Among 38
samples; 20 patients were with prostatic adenocarcinoma, 18 patients were with high-grade prostatic
intraepithelial neoplasia and adjacent normal prostatic tissue areas. The immunolocalisation of apelin
and apelin receptor in these tissues were determined immunohistochemically. Results: Apelin and
apelin receptor expressions were higher in prostatic adenocarcinoma than normal prostate tissue
and high-grade prostatic intraepithelial neoplasia. Apelin receptor expression was also increased in
high-grade prostatic intraepithelial neoplasia compared to normal tissue. Conclusion: Apelin and
apelin receptor are increase in the process of prostate carcinogenesis. This increase may adversely
affect the clinical course of prostate cancer patients by stimulating angiogenesis, which is important
for invasion and metastasis in prostate cancer