Effect of surgically guided axonal regrowth into a 3-way-conduit (isogeneic trifurcated aorta) on functional recovery after facial-nerve reconstruction: Experimental study in rats

Bendella H., Rink S., Manthou M., Papamitsou T., Nakamura M., Angelov D. N., ...Daha Fazla

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, cilt.37, sa.2, ss.181-196, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3233/rnn-190899
  • Dergi Adı: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.181-196
  • Anahtar Kelimeler: Facial nerve, hypoglossal nerve, facial-facial anastomosis (FFA), hypoglossal-facial anastomosis (HFA), aortic 3-way-conduit, MOTOR END-PLATES, MANUAL STIMULATION, SCHWANN-CELLS, SCIATIC-NERVE, VIBRISSAL MOVEMENT, GROWTH-FACTOR, IN-VIVO, REINNERVATION, REGENERATION, MUSCLE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: The "post-paralytic syndrome" after facial nerve reconstruction has been attributed to (i) malfunctioning axonal guidance at the fascicular (branches) level, (ii) collateral branching of the transected axons at the lesion site, and (iii) intensive intramuscular terminal sprouting of regenerating axons which causes poly-innervation of the neuromuscular junctions (NMJ).