Central neuropeptide-S administration alleviates stress-induced impairment of gastric motor functions through orexin-A


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BÜLBÜL M., SİNEN O., BAYRAMOGLU O.

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.31, no.1, pp.65-72, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.5152/tjg.2020.18626
  • Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.65-72
  • Keywords: Neuropeptide-S, orexin-A, gastric emptying, acute restraint stress, CORTICOTROPIN-RELEASING-FACTOR, RESTRAINT STRESS, RECEPTOR GENE, BRAIN-STEM, MOTILITY, NEURONS, CRF, RESPONSES, NUCLEUS, AROUSAL
  • Akdeniz University Affiliated: Yes

Abstract

Background/Aims: The novel brain peptide neuropeptide-S (NPS) is produced exclusively by a small group of cells adjacent to the noradrenergic locus coeruleus. The NPSR mRNA has been detected in several brain areas involved in stress response and autonomic outflow, such as amygdala and hypothalamus, suggesting that central NPS may play a regulatory role in stress-induced changes in gastrointestinal (GI) motor functions. In rodents, exogenous central NPS was shown to inhibit stress-stimulated fecal output. Moreover, exogenous NPS was demonstrated to activate hypothalamic neurons that produce orexin-A (OXA), which has been shown to stimulate postprandial gastric motor functions via central vagal pathways. Therefore, we tested whether OXA mediates the NPS-induced alterations in gastric motor functions under stressed conditions.