Assessment of tumors in children with tuberous sclerosis: a single centre's experience

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Emir S., Hacisalihoglu S., Ozyoruk D., Ekici F., Degerliyurt A., Guven A., ...More

TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS, vol.52, no.1, pp.30-34, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.5152/turkpediatriars.2017.4309
  • Journal Name: TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.30-34
  • Keywords: Angiomyolipoma, rhabdomyoma, subependymal giant cell astrocytoma, tuberosclerosis, tumor, COMPLEX, PREVALENCE, POPULATION, DIAGNOSIS
  • Akdeniz University Affiliated: Yes

Abstract

Aim: As a result of mutations in TSC1 (9q34) and TSC2 (16p13.3) tumor supressor genes, the mammalian target of the rapamycin (mTor) signaling pathway is overactivated in patients with tuberous sclerosis. Abnormal cell proliferation and differentiation is responsible for the growth several different tumors. The aim of this study was to review tumors in our patients with tuberous sclerosis.