A study detection of the ROS1 gene fusion by FISH and ROS1 protein expression by IHC methods in patients with ovarian malignant or borderline serous tumors

Aydin H. A., Pestereli E., ÖZCAN M., Bayramoglu Z., ERDOĞAN G., ŞİMŞEK T.

PATHOLOGY RESEARCH AND PRACTICE, cilt.214, sa.11, ss.1868-1872, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 214 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.prp.2018.09.016
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1868-1872
  • Anahtar Kelimeler: FISH, Immunohistochemistry, ROS1, Ovarian serous tumors, LUNG-CANCER, ABRIDGED-REPUBLICATION, STAGING CLASSIFICATION, TYROSINE KINASE, FALLOPIAN-TUBE, PERITONEUM
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: ROS1 is an orphan receptor protein tyrosine kinase which is supposed to undergo genetic rearrangement in carcinogenesis. In the current study, we aimed to investigate the frequency and clinicopathologic features associated with ROS1 gene fusion and ROS1 protein expression in patients with ovarian serous carcinoma or serous borderline tumors.