Akademik Veri Yönetim Sistemi
Global emergency and critical care (Online), cilt.2, sa.1, ss.8-12, 2023 (Hakemli Dergi)
Objective: Acute ischemic stroke is an emergency clinical condition resulting from occlusion of intracranial arteries leading to neural tissue destruction. In this study, we evaluated whether lactate levels and monocyte/high-density lipoprotein (HDL) ratio can be used as a marker in predicting treatment outcomes in patients who underwent intravenous thrombolysis (IVT) or mechanical thrombectomy (MT) after IVT. Materials and Methods: In this retrospective study, demographic data, clinical status, radiological results, laboratory data, the National Institutes of Health Stroke Scale (NIHSS) scores on admission and after treatment, and clinical data of patients who were diagnosed with acute ischemic stroke and underwent IVT or IVT + MT between January 01, 2019 and December 31, 2019 in the Emergency Medicine Clinic of University of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital were evaluated. The vessels of the patients causing ischemic pathology were evaluated and divided into three groups as middle cerebral artery (MCA), posterior cerebral artery (PCA), and anterior cerebral artery (ACA). The distribution of quantitative data was evaluated using the Kolmogorov-Smirnov test. The Kruskal-Wallis and Mann-Whitney U tests was used to compare independent quantitative data between groups. Results: A total of 189 cases (male: 57.7%) with a mean age of 69.5±12.9 years were included in our study. Monocytes/HDL and lactate levels were similar between the MCA, PCA, and ACA groups. The total cholesterol/HDL ratio was found to be significantly higher in the PCA group than in the MCA group (p<0.05). There was a significant decrease in the NIHSS scores of the patients after treatment compared with the scores at the time of admission (p<0.05). No significant differences between the groups were observed with regard to the changes in NIHSS scores. Conclusion: It was shown that monocyte/HDL ratio and lactate levels were not significant in predicting the success of treatment and neurological improvement in patients with acute ischemic stroke.