Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration
NEUROTOXICITY RESEARCH, cilt.7, sa.3, ss.243-250, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 3
- Basım Tarihi: 2005
- Doi Numarası: 10.1007/bf03036453
- Dergi Adı: NEUROTOXICITY RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.243-250
- Anahtar Kelimeler: apoptosis, all-trans retinoic acid, 9-cis retinoic acid, 13-cis retinoic acid, amyloid-beta, hippocampal neurons, ALVEOLAR EPITHELIAL-CELLS, ALZHEIMERS-DISEASE, DEGENERATING NEURONS, LIPID-PEROXIDATION, INDUCED APOPTOSIS, OXIDATIVE STRESS, IN-VITRO, ACTIVATION, PEPTIDE, PROLIFERATION
- Akdeniz Üniversitesi Adresli: Evet
Özet
Attenuating amyloid-beta mediated neurodegeneration is of major therapeutic consideration in the potential treatment of Alzheimer disease. Previously, we found that a high dietary consumption of retinoic acid was associated with a reduced incidence of Alzheimer disease. Therefore, in this study, we investigated whether amyloid-beta mediated cell death in primary hippocampal neurons could be prevented by retinoic acid isomers. Our results suggest that retinoic acid isomers, including all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, may play an important role in protecting neurons from amyloid-beta-induced cell death. Retinoic acid may therefore afford a novel therapeutic mechanism for the treatment and prevention of Alzheimer disease.