Effects of propylthiouracil treatment on antioxidant activities in blood of toxic multinodular goiter patients
PHARMACOLOGY, cilt.61, sa.1, ss.31-36, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 1
- Basım Tarihi: 2000
- Doi Numarası: 10.1159/000028377
- Dergi Adı: PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.31-36
- Anahtar Kelimeler: hyperthyroidism, propylthiouracil, antioxidant, lipid peroxidation, LIPID-PEROXIDATION, HYPERTHYROID PATIENTS, SUPEROXIDE-DISMUTASE, THYROID-HORMONES, ANIMAL-TISSUES, SUPPLEMENTATION, SELENIUM, ASSAY, ERYTHROCYTES, AUTOXIDATION
- Akdeniz Üniversitesi Adresli: Evet
Özet
Erythrocyte, serum and plasma antioxidant activities a nd the effects of propylthiouracil (PIU) treatment on these activities were studied in patients with toxic multinodular goiter, The activities of the erythrocyte antioxidant enzymes (glucose-6-phosphate dehydrogenase, catalase, Cu/Zn-superoxide dismutase, selenium (Se)-dependent glutathione peroxidase and glutathione reductase) and the levels of erythrocyte Se, serum ceruloplasmin and plasma malondialdehyde were significantly higher while serum vitamin E, plasma vitamin C and plasma Se were lower in hyperthyroid patients. PTU treatment, not for 1 but for 3 months caused a partial reversal of antioxidant activities to euthyroid levels. It is suggested that alterations in blood antioxidant activities following PTU treatment might be due to the antioxidant and/or antithyroid effect of this drug, Copyright (C) 2000 S. Karger AG, Basel.