PHARMACOLOGY, vol.61, no.1, pp.31-36, 2000 (SCI-Expanded)
Erythrocyte, serum and plasma antioxidant activities a nd the effects of propylthiouracil (PIU) treatment on these activities were studied in patients with toxic multinodular goiter, The activities of the erythrocyte antioxidant enzymes (glucose-6-phosphate dehydrogenase, catalase, Cu/Zn-superoxide dismutase, selenium (Se)-dependent glutathione peroxidase and glutathione reductase) and the levels of erythrocyte Se, serum ceruloplasmin and plasma malondialdehyde were significantly higher while serum vitamin E, plasma vitamin C and plasma Se were lower in hyperthyroid patients. PTU treatment, not for 1 but for 3 months caused a partial reversal of antioxidant activities to euthyroid levels. It is suggested that alterations in blood antioxidant activities following PTU treatment might be due to the antioxidant and/or antithyroid effect of this drug, Copyright (C) 2000 S. Karger AG, Basel.