Effects of propylthiouracil treatment on antioxidant activities in blood of toxic multinodular goiter patients

Ozdem S., Aliciguzel Y., Ozdem S., Karayalcin U.

PHARMACOLOGY, vol.61, no.1, pp.31-36, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 1
  • Publication Date: 2000
  • Doi Number: 10.1159/000028377
  • Journal Name: PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.31-36
  • Keywords: hyperthyroidism, propylthiouracil, antioxidant, lipid peroxidation, LIPID-PEROXIDATION, HYPERTHYROID PATIENTS, SUPEROXIDE-DISMUTASE, THYROID-HORMONES, ANIMAL-TISSUES, SUPPLEMENTATION, SELENIUM, ASSAY, ERYTHROCYTES, AUTOXIDATION
  • Akdeniz University Affiliated: Yes

Abstract

Erythrocyte, serum and plasma antioxidant activities a nd the effects of propylthiouracil (PIU) treatment on these activities were studied in patients with toxic multinodular goiter, The activities of the erythrocyte antioxidant enzymes (glucose-6-phosphate dehydrogenase, catalase, Cu/Zn-superoxide dismutase, selenium (Se)-dependent glutathione peroxidase and glutathione reductase) and the levels of erythrocyte Se, serum ceruloplasmin and plasma malondialdehyde were significantly higher while serum vitamin E, plasma vitamin C and plasma Se were lower in hyperthyroid patients. PTU treatment, not for 1 but for 3 months caused a partial reversal of antioxidant activities to euthyroid levels. It is suggested that alterations in blood antioxidant activities following PTU treatment might be due to the antioxidant and/or antithyroid effect of this drug, Copyright (C) 2000 S. Karger AG, Basel.