ACTA MEDICA MEDITERRANEA, vol.30, no.4, pp.801-804, 2014 (SCI-Expanded)
Background and objectives
: Erdosteine, a thiol derivative in the same group as N-acetyl cysteine, belongs to a class of medicines
called expectorants.
Aim
: It was aimed to determine effects of erdosteine (ERD) on coagulation.
Material and methods
: A total of 23 female rats were divided into three groups as control (C) (n=7), ERD-10 (n=7), ERD-50
(n=9). Rats in C group were given dilution of 0.3 ml sodium bicarbonate [NaHCO3]; rats in ERD-10 group were given 10 mg/kg
ERD; and rats in ERD-50 group were given 50 mg/kg ERD. The drugs were given for ten days by oral gavage. Blood samples were
drawn from the heart 24 hours after the last drug dose, and coagulation parameters were measured with automated analyzers.
Results: While Factor VIII and AT-III levels decreased in both ERD-10 and ERD-50 group, Factor IX levels only decreased in
ERD-50 group. Also, INR, PT and aPTT were prolonged in the ERD-50 group compared with the control and ERD-10 groups. There
was no significant difference between groups for protein C and S.
Conclusion
: The results showed that erdosteine may increase bleeding tendencies in a dose-related manner. Therefore, we suggest
that it should be noted when erdosteine is used together with anticoagulant medications. In addition, patients should be questioned
regarding the use of erdosteine before dental or medical operations in order to prevent bleeding abnormalities.