DNA Methylation in Forensic Human Identification

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Öğr. Gör. Dr. AYŞE MERVE ÖRME

Tez Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: University of London-Queen Mary and Westfield College, Barts and The London School of Medicine and Dentistry, Forensic Medical Sciences, İngiltere

Tez Danışmanı: Professor Peter Vanezis Obe

Tezin Onay Tarihi: 2017

Tezin Dili: İngilizce

Desteklendiği Program: Diğer

Özet:

DNA methylation is the addition of a methyl group (-CH3) to the fifth carbon of a cytosine base that is available in terms of CG dinucleotides. The most common examples of DNA methylation usage in forensic examinations are body fluid identification, age estimation, sex determination, ancestral identification, and monozygotic twin’s discrimination. More extensive investigations of criminological epigenetics would help for additional identification of convenient epigenetic markers, more convincing connections between cell differentiation and aging to epigenetic impacts, and would reveal further insight on a set of forensic practices.