Development of therapeutic options on type 2 diabetes in years: Glucagon-like peptide-1 receptor agonist's role intreatment; from the past to future.


Dogruel H., BALCI M. K.

World journal of diabetes, cilt.10, sa.8, ss.446-453, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4239/wjd.v10.i8.446
  • Dergi Adı: World journal of diabetes
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.446-453
  • Anahtar Kelimeler: Incretin-basedtherapy, Incretin mimetics, Glucagon-like peptide-1 receptor agonist, Dipeptidyl peptidase-4 inhibitor, BLOOD-GLUCOSE CONTROL, EVALUATING CARDIOVASCULAR OUTCOMES, GASTRIC-INHIBITORY POLYPEPTIDE, BASE-LINE CHARACTERISTICS, INSULIN-SECRETION, DPP-4 INHIBITORS, GLP-1 AGONISTS, HEART-FAILURE, WEIGHT-LOSS, 7-36 AMIDE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia. Type 2 diabetes (T2DM) accounting for 90% of cases globally. The worldwide prevalence of DM is rising dramatically over the last decades, from 30 million cases in 1985 to 382 million cases in 2013. It's estimated that 451 million people had diabetes in 2017. As the pathophysiology was understood over the years, treatment options for diabetes increased. Incretin-based therapy is one of them. Glucagon-like peptide-1 receptor agonise (GLP-1 RA) not only significantly lower glucose level with minimal risk of hypoglycemia but also, they have an important advantage in themanagement of cardiovascular risk and obesity. Thus, we will review here GLP-1 RAsrole in the treatment of diabetes.