Effects of high-dose intravenous immunoglobulin on lipopolysaccharide-induced acute lung injury

OYGUCU S. E., ÖZBUDAK İ. H., AKCAN A. B., COŞKUN M., Ozel D., ÖZBİLİM G., ...Daha Fazla

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.21, sa.1, ss.51-55, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.intimp.2014.04.002
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-55
  • Anahtar Kelimeler: Acute lung injury, Immunoglobulin, Transforming growth factor beta (TGF-beta), Inflammation, TUMOR-NECROSIS-FACTOR, GROWTH-FACTOR-BETA, RESPIRATORY-DISTRESS-SYNDROME, PULMONARY-FIBROSIS, RAT MODEL, TGF-BETA, INFLAMMATORY RESPONSE, MONOCLONAL-ANTIBODY, CONTROLLED-TRIAL, IMMUNE GLOBULIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose: Intravenous immunoglobulin (IVIG) therapy is used in inflammatory diseases but the use of immunoglobulin as a treatment for acute lung injury (ALI) has not been previously studied. Transforming growth factor beta (TGF-beta) plays a critical role in the pathogenesis of of ALI. Therefore we examined the levels of TGF-beta and lung inflammation scores in WIG treated ALI models.