Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients


Kocak H., Gumuslu S., Ermis C., Mahsereci E., Sahin E., Gocmen A. Y., ...More

AMERICAN JOURNAL OF NEPHROLOGY, vol.28, no.1, pp.91-96, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1159/000109397
  • Journal Name: AMERICAN JOURNAL OF NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.91-96
  • Keywords: carotid intima media thickness, peritoneal dialysis, oxidative stress, asymmetric dimethylarginine, GLYCATION END-PRODUCTS, CARDIOVASCULAR-DISEASE, LIPID-PEROXIDATION, OXIDANT STRESS, RISK-FACTORS, ATHEROSCLEROSIS, HEMODIALYSIS, PROTEIN, SERUM
  • Akdeniz University Affiliated: Yes

Abstract

Backgrounds: Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as nonclassical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with common carotid artery intima media thickness (CIMT) in peritoneal dialysis (PD) patients. Methods: Thirty PD patients without known atherosclerotic disease and classical cardiovascular risk factors as well as age- and gender-matched 30 healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end product (AGE), pentosidine, advanced oxidation protein products ( AOPP), ADMA and CIMT in each subjects. Results: TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PD patients than in controls (p < 0.001). CIMT in patients was higher than in the control group (0.83 +/- 0.09 vs. 0.77 +/- 0.06 mm; p < 0.01). CIMT was independently correlated with TBARS (beta = 0.33, p < 0.01), MDA (beta = 0.27, p < 0.01), AOPP (beta = 0.22, p < 0.02), AGE (beta = 0.45, p 0.01), pentosidine (beta = 0.56, p < 0.01) and ADMA (beta = 0.54, p < 0.01). Conclusions: OS markers and serum ADMA levels independently predict the CIMT level in PD patients. Copyright (c) 2007 S. Karger AG, Basel.