Investigation of the genotoxic and antigenotoxic properties of essential oils obtained from two Origanum species by Drosophila wing SMART assay

Demir E., KAYA B., Marcos R., KOCAOĞLU CENKCİ S., ÇETİN H.

TURKISH JOURNAL OF BIOLOGY, vol.37, no.2, pp.129-138, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.3906/biy-1205-64
  • Journal Name: TURKISH JOURNAL OF BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.129-138
  • Keywords: Drosophila, antigenotoxicity, Origanum onites, Origanum minutiflorum, cobalt chloride, potassium dichromate, OREGANO ESSENTIAL OIL, SPOT-TEST, SOMATIC MUTATION, IN-VIVO, ANTIOXIDANT ACTIVITY, COBALT COMPOUNDS, AQUEOUS EXTRACT, MUTAGENICITY, MELANOGASTER, METAL
  • Akdeniz University Affiliated: Yes

Abstract

In this study, essential oils extracted from 2 species of oregano, Origanum onites L. and Origanum minutiflorum O.Schwarz & P.H.Davis, were assayed for genotoxicity using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Results indicated that there is no significant genotoxic effect of the 2 oils tested. In addition, the antigenotoxic activities of these oils against potassium dichromate (K2Cr2O7) and cobalt chloride (CoCl2) were tested. Results indicated that essential oil cotreatments were able to abolish the genotoxic effects induced by the 2 metal compounds. It is suggested that the observed effects can be linked to the antioxidant properties of the selected essential oils. Moreover, these in vivo results will contribute to the antigenotoxicity database of the 2 Origanum species used in this study.