Effect of renal transplantation on endothelial function in haemodialysis patients


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KOCAK H., CEKEN K., YAVUZ A., YUCEL S., GURKAN A., Erdogan O., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.21, no.1, pp.203-207, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1093/ndt/gfi119
  • Journal Name: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.203-207
  • Keywords: endothelial dysfunction haemodialysis, renal transplantation, DEPENDENT VASODILATION, NITRIC-OXIDE, CARDIOVASCULAR-DISEASE, CONDUIT ARTERIES, DYSFUNCTION, FAILURE, RISK
  • Akdeniz University Affiliated: Yes

Abstract

Background. Haemodialysis patients (HD) have been characterized by a high incidence and prevalence of atherosclerotic cardiovascular disease. Based on the traditional cardiovascular risk factors in this population, we cannot explain this high incidence and prevalence. One of the mechanisms contributing to cardiovascular risk in HD patients may be to uraemic toxins. Cardiovascular risk factors and uraemic toxins themselves may cause endothelial dysfunction, which may play a pivotal role in the development and progression of atherosclerosis in this population. We hypothesized that elimination of uraemic toxins in response to renal transplantation (RTx) can improve endothelial function as assessed by flow-mediated dilatation of brachial artery in haemodialysis (HD) patients.