Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells


Afsar E., KIRIMLIOĞLU E., ÇEKER T., YILMAZ C., DEMİR N., Aslan M.

REDOX BIOLOGY, vol.30, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2020
  • Doi Number: 10.1016/j.redox.2020.101430
  • Journal Name: REDOX BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Directory of Open Access Journals
  • Keywords: Sphingolipid, Tunicamycin, Retinal pigment epithelial cells, ENDOPLASMIC-RETICULUM STRESS, UNFOLDED PROTEIN RESPONSE, CERAMIDE, ACTIVATION, DEATH, CERAMIDE-1-PHOSPHATE, SYNTHASE, CALPAIN
  • Akdeniz University Affiliated: Yes

Abstract

Background: We aimed to determine sphingolipid levels and examine apoptotic pathways in human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) stress.