Doxorubicin for prevention of epineurial fibrosis in a rat sciatic nerve model: outcome based on gross postsurgical, histopathological, and ultrastructural findings Laboratory investigation

Albayrak B. S., İSMAİLOĞLU Ö., Ilbay K., Yaka U., TANRIÖVER G., Gorgulu A., ...Daha Fazla

JOURNAL OF NEUROSURGERY-SPINE, cilt.12, sa.3, ss.327-333, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3171/2009.9.spine09407
  • Dergi Adı: JOURNAL OF NEUROSURGERY-SPINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.327-333
  • Anahtar Kelimeler: doxorubicin, epineural fibrosis, sciatic nerve, rat, RETROGRADE AXOPLASMIC-TRANSPORT, PERIPHERAL-NERVE, INDUCED INHIBITION, ADJUVANT CHEMOTHERAPY, COLLAGEN BIOSYNTHESIS, SCAR FORMATION, MITOMYCIN-C, MEDIAN NERVE, ADRIAMYCIN, SURGERY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Object. Epineural fibrosis may complicate peripheral nerve surgeries and currently is considered as one of the main factors responsible for failed surgeries. The authors investigated the postoperative antiscarring effects of topically applied doxorubicin (DXR) on rat sciatic nerves.