Is the effect of melatonin on vascular endothelial growth factor receptor-2 associated with angiogenesis in the rat ovary?

Kandemir Y. B., Konuk E., KATIRCI E., Xxx F., Behram M.

CLINICS, vol.74, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74
  • Publication Date: 2019
  • Doi Number: 10.6061/clinics/2019/e658
  • Journal Name: CLINICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Melatonin, Ovary, VEGF, VEGFR1, VEGFR2, DIFFERENT REPRODUCTIVE PHASES, EXOGENOUS MELATONIN, TUMOR ANGIOGENESIS, OXIDATIVE STRESS, NERVE INJURY, ANNUAL CYCLE, PROGESTERONE, PRESERVATION, ACTIVATION, ANTIOXIDANT
  • Akdeniz University Affiliated: Yes

Abstract

OBJECTIVES: Vascular endothelial growth factor (VEGF) and its receptors play important roles in angiogenesis. Melatonin plays an important role in gonadal development; thus, its effect on the reproductive system is evident. We investigated the influence of melatonin on the expression of VEGF, vascular endothelial growth factor receptor-1 (VEGFR1) and vascular endothelial growth factor receptor-2 (VEGFR2), as well as on changes in oxidative stress markers and follicle numbers in rat ovaries.