Prediction of live birth and cumulative live birth rates in freeze-all-IVF treatment of a general population

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Ozgur K., Bulut H., Berkkanoglu M., DÖNMEZ L., Coetzee K.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.36, sa.4, ss.685-696, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s10815-019-01422-z
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.685-696
  • Anahtar Kelimeler: Live birth, Cumulative live birth, freeze-all, Blastocyst, Vitrification, Frozen embryo transfer, FROZEN EMBRYO-TRANSFER, ASSISTED REPRODUCTIVE TECHNOLOGY, DIMINISHED OVARIAN RESERVE, IN-VITRO FERTILIZATION, BLASTOCYST FORMATION, TRANSFER STRATEGY, FRESH, CYCLE, STIMULATION, ANEUPLOIDY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

PurposeTo investigate the cumulative live birth (cLB) rate of one complete freeze-all-IVF cycle in a general infertile population and to investigate patient and treatment variables that predict blastocyst development and live birth (LB).MethodIn a retrospective observational study, the data of all IVF cycles performed between 1 February 2015 and 31 January 2016 at a single IVF centre was investigated. In the study, patient-couples were followed up for 18months following oocyte retrieval. After exclusions, the patient and treatment variables of 1582 patient-couples who underwent treatment were included in the analyses.ResultsThe median time interval between the oocyte retrieval attempt and the frozen embryo transfer (FET) in which LB was achieved was 38.0 (35.0-67.0)days. The variables of freeze-all-IVF cycles with single blastocyst FET selected by multiple logistic regression to predict LB significantly were female age, infertility duration, FET number (i.e. 1st, 2nd, or 3rd FET), and blastocyst quality. In a regression adjusting for female age, the number of blastocysts transferred, and oocyte number group (1-3, 4-9, 10-15, and >15), none of the oocyte number groups were selected to predict LB of 1st FET, significantly. While the per transfer LB rates decreased linearly from the 1st (56.5%) to the 3rd (36.4%) FET, the cLB rate increased from 47.3% after the 1st FET to 55.0% after a 3rd possible FET.ConclusionThe cLB rate of one complete freeze-all-IVF cycle of a general infertile population, with 18-month follow-up, was 55.0%. In freeze-all-IVF, ovarian reserve variables were not selected by regression models to predict LB, significantly.