Presence of S100A8/Gr1-Positive Myeloid-Derived Suppressor Cells in Primary Tumors and Visceral Organs Invaded by Breast Carcinoma Cells

Tanriover G., EYINC M. B., ALIYEV E., Dilmac S., ERIN N.

CLINICAL BREAST CANCER, cilt.18, sa.5, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.clbc.2018.03.013
  • Dergi Adı: CLINICAL BREAST CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Breast cancer, GR1, Immunohistochemistry, MDSC, S100A8/A9, S100 PROTEINS, CANCER, INFLAMMATION, LIVER, EXPRESSION, PATTERN, DIFFERENTIATION, CARCINOGENESIS, AGGRESSIVENESS, NEUTROPHILS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

In a study performed to determine S100A8/A9 and coexpression of Gr1 in metastatic breast carcinoma, we found that that tumor-derived factors may increase S100A8/A9-positive cells locally and systemically. We also showed that S100A8/A9 positive cells were increased in metastatic lesions. S100A8/A9-positive cells may be an appropriate milieu for the formation of metastasis and may be used to predict the metastatic potential of primary breast tumors.