Neoangiogenesis and expression of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas


ÖZBUDAK İ. H., KARAVELI S., SIMSEK T., ERDOĞAN G., PESTERELI E.

GYNECOLOGIC ONCOLOGY, vol.108, no.3, pp.603-608, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.ygyno.2007.11.028
  • Journal Name: GYNECOLOGIC ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.603-608
  • Keywords: HIF-1 alpha, VEGF, GLUT-1, neoangiogenesis, endometrium adenocarcinoma, TUMOR ANGIOGENESIS, FACTOR 1-ALPHA, CARCINOMA, METASTASIS, PROGNOSIS, 2-ALPHA, BIOLOGY, CANCER, GLUT-1
  • Akdeniz University Affiliated: Yes

Abstract

Objective. Hypoxia Inducible Factor-lot (HIF-1 alpha) is a transcriptional factor that activates multiple genes including Vascular Endothelial Growth Factor (VEGF) and glucose transporter-1 (GLUT-1) in response to hypoxia and promotes neoangiogenesis.