Comparison of the effects of fluoxetine and venlafaxine on bone healing in a rat calvarial defect model

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ERDEM A. S., ŞİMŞEK KAYA G., KAYA M., ALTUNAY B., ALKAN T. Y., TORU H. S.

Injury, vol.54, no.6, pp.1439-1443, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1016/j.injury.2023.03.034
  • Journal Name: Injury
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Abstracts in Social Gerontology, Aerospace Database, CINAHL, Communication Abstracts, EMBASE, Metadex, SportDiscus, Civil Engineering Abstracts
  • Page Numbers: pp.1439-1443
  • Keywords: Bone defect healing, Fluoxetine, Rat, Venlafaxine
  • Akdeniz University Affiliated: Yes

Abstract

Objective: The purpose of this study was to compare the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the serotonin-norepinephrine reuptake inhibitor (SNRI) venlafaxine on bone defect healing. Materials and Methods: Wistar rats were randomly divided into three groups of eight animals each. The first received 0.1 ml/kg sterile saline solution, the second 5 mg/kg fluoxetine, and the third 5 mg/kg venlafaxine, daily by gastric gavage over 7 weeks. At week 3 of drug therapy, 5-mm diameter calvarial defects were created in the parietal bone of all of the animals. All rats were euthanized four weeks after surgery, micro-CT analysis and histomorphometric analysis were carried out to evaluate the following parameters: Bone volume fraction (BV/TV), bone surface (BS), bone surface density (BS/BV; bone surface/bone volume, 1/mm), trabecular number (Tb. N), trabecular thickness (Tb. Th), areas of new bone structure (positive areas), areas of mature bone structure (negative areas). Results: Micro-CT analysis showed the presence of similar levels of bone formation within the defect site in all three groups (p>0.05). Histomorphometric analysis revealed the presence of bone-forming cells at the defect periphery, with less activity indicating bone formation at the center. No statistically significant difference was observed between the groups (p>0.05). Conclusion: Based on the findings of this study, it can be said that the use of both antidepressants hasn't any effect on bone defect healing.