The Prognostic Significance of the Expression of Insulin-Like Growth Factor Receptor-I in Prostate Cancer


Korcum A. F., Tekeli E., Aksu G., ERDOĞAN G., Ciftcioglu A.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.19, no.4, pp.223-231, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2009
  • Journal Name: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.223-231
  • Keywords: Prostate Cancer, Radiotherapy, IGF-IR expression, FREE SURVIVAL, IGF AXIS, PROGRESSION, METASTASIS, MECHANISMS, COMPONENTS, INVASION, CELLS, EZH2
  • Akdeniz University Affiliated: Yes

Abstract

We aimed to investigate the expression of IGF-IR in prostate cancer and to evaluate their prognostic significance. Between 1999 and 2007, the expression of IGF-IR was investigated by using an immunohistochemical approach in fifty-nine prostate cancer patients who were treated with radiotherapy. Median age was 73 (ranged 56-83) years and median follow up was 48.3 months. Fourty-three patients (73%) were found be IGF-IR positive. Biochemically freedom from relapse free survival was significantly higher in patients with negative stained IGF-IR, age < 70, Gleason score < 8. PSA(0) value <= 20 ng/ml. Multivariate analysis demonstrated that PSA0 value <= 20 ng/ml and PSA2 value <= 0.36 ng/ml were statistically significant predictors of biochemically freedom from relapse free survival. The 4-year overall survival, biochemically freedom from relapse free and distant metastasis free survival were 76%, 80% and 93% respectively. This study demostrated that presence of IGF-IR expression was significantly associated with better biochemically freedom from relapse free survival rates.