Effects of lycopene and apigenin on human umbilical vein endothelial cells in vitro under angiogenic stimulation

ŞAHİN M., Sahin E., GÜMÜŞLÜ S.

ACTA HISTOCHEMICA, cilt.114, sa.2, ss.94-100, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.acthis.2011.03.004
  • Dergi Adı: ACTA HISTOCHEMICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.94-100
  • Anahtar Kelimeler: Angiogenesis, Lycopene, Apigenin, Cancer, HUVEC, PROSTATE-CANCER RISK, HUMAN HEPATOMA-CELLS, PROLIFERATION, APOPTOSIS, MIGRATION, CAROTENOIDS, EXPRESSION, FLAVONOIDS, ADHESION, INVASION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Angiogenesis is the formation process of new blood vessels from preexisting vessels. Solid tumors need angiogenesis for growth and metastasis. The suppression of tumor growth by inhibition of neoangiogenic processes represents a potential approach to cancer treatment. Lycopene has powerful antioxidant capacities and anticarcinogenic properties. The aim of this study was to investigate the effects of lycopene on angiogenesis in vitro. For this reason, we measured in vitro angiogenesis in human umbilical vein endothelial cells including parameters of cell proliferation, tube formation, cell migration. Lycopene and apigenin were observed to block the endothelial cell proliferation in a dose-dependent manner. In addition, they significantly decreased the capillary-like tube lengths, tube formation and endothelial cell migration. This study provides indications that apigenin and lycopene, which are considered as chemopreventive agents, to be effective in vitro on endothelial cells and angiogenesis. (C) 2011 Elsevier GmbH. All rights reserved.