A Retrospective Analysis of Pregnancy Outcomes after Kidney Transplantation in a Single Center


Akar M., Ozekinci M., SANHAL C. Y., Kececioglu N., Mendilcioglu İ. İ., ŞENOL Y., ...More

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, vol.79, no.1, pp.13-18, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 79 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1159/000365815
  • Journal Name: GYNECOLOGIC AND OBSTETRIC INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-18
  • Keywords: Renal transplant recipient, Immunosuppression, Pregnancy, RENAL-TRANSPLANTATION, THERAPY, RISK, REPRODUCTION, RECIPIENTS, ISSUES
  • Akdeniz University Affiliated: Yes

Abstract

Background: We reported pregnancy outcomes after kidney transplantation in a single transplant center. Methods: We reviewed the perinatal outcomes of female kidney transplant patients of reproductive age (18-40 years) from 1987 to 2011. Results: A total of 246 patients were reviewed. Of these, 43 women registered a pregnancy following kidney transplantation. The mean patient age was 31.3 +/- 4.2 years (range 24-40). The mean transplant-conception interval was 35.9 +/- 12.6 months (range 24-120); 9 patients had a cadaveric allograft. The human leukocyte antigen match was >= 3/6 for 34 patients. The rate of live births was 29/43 (67.4%), miscarriage 10/43 (23.2%), preterm delivery 7/29 (24.1%), preeclampsia 5/29 (17.2%), and intrauterine growth retardation 2/29 (6.9%). Overall, 3/29 patients (10.3%) received a blood transfusion during pregnancy due to persistent symptomatic anemia, despite iron replacement and erythropoietin therapy; 24 patients (82%) had a cesarean section delivery; 3 patients had kidney rejection during pregnancy, with 2 occurring during the 6th postpartum month. Conclusion: Pregnancy should be considered a high risk in renal transplant recipients, necessitating close follow-up. (C) 2014 S. Karger AG, Basel