Toxicity of Thiamethoxam and Piperonyl Butoxide Combination against some Strains of House Fly Musca domestica L. (Diptera) in Turkey

Polat B., ÇETİN H.

ACTA ZOOLOGICA BULGARICA, vol.72, no.2, pp.321-324, 2020 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 2
  • Publication Date: 2020
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.321-324
  • Keywords: House fly, piperonyl butoxide, synergist, thiamethoxam, NEONICOTINOIDS, TRANSMISSION
  • Akdeniz University Affiliated: Yes


In recent years, the use of neonicotinoids against both agricultural and public health pests has increased significantly. These insecticides are highly effective against many insects but in the last two decades the toxic effects of neonicotinoids on non-target organisms and resistance development in target insects were reported. Synergistic agents may be used to reduce the rate of neonicotinoid application and to increase their effectiveness. Piperonyl butoxide (PBO) is not a pesticide itself and acts as a synergist of insecticides or acaricides by inhibiting the cytochrome P450-mediated metabolism of pesticides. The aim of this study was to test in laboratory conditions whether PBO has synergistic effect on thiamethoxam on four Turkish strains (Diyarbakir, Adana, Gaziantep and Kahrammunaras) of the house fly Musca domestica L. When the synergist was added, the knock down fifty time (KDT50) ratios were significantly reduced in all populations. The presence of PBO in the test solution increased the toxicity of thiamethoxam on Kahramanmaras, Adana and Diymbakir house fly strains at both application doses (0.125 and 0.25 g active ingredient/m(2)). According to these results, PBO can help coping with neonicotinoid resistance. Resistance and efficacy tests should be performed for all house fly populations and the use of synergist rates should be evaluated according to the results of the tests.