Hybrid Tomo-Helical and Tomo-Direct radiotherapy for localized prostate cancer

Creative Commons License

Karaca S., Koca T., Sarpün İ. H., Tunçel N., Korcum Şahin A. F.

JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, cilt.22, sa.10, ss.136-143, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/acm2.13406
  • Dergi Adı: JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.136-143
  • Anahtar Kelimeler: hybrid radiotherapy, localized prostate cancer, Tomo-Direct, Tomo-Helical, MODULATED ARC THERAPY, RADIATION-THERAPY, CONVENTIONAL RADIOTHERAPY, CONFORMAL RADIOTHERAPY, 70 GY, DOSIMETRY, TOXICITY, IMRT
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose The aim of the study is to present a new planning approach to provide better planning target volume (PTV) coverage and reduce bladder and rectum dose with hybrid Tomo-Helical (TH)/Tomo-Direct (TD) radiotherapy (RT) for localized prostate cancer (LPC). Methods Twenty-five LPC patients were included in this retrospective study. TH plans, TD plans, and hybrid TH/TD plans were created. Lateral beams were used for the hybrid TD plan and the prescribed dose was 70 Gy in 28 fractions (hybrid plans were combined 45 Gy/ 18 fxs for TH and 25 Gy/10 fxs for TD). Doses of PTV (D2%, D98%, D50%, homogeneity index (HI), conformity index (CI), coverage) and organs at risk (OARs) (V50%, V35%, V25%, V5%, and V95%) were analyzed. The Wilcoxon signed-rank test was used to analyze the difference in dosimetric parameters. p-Value TH plans showed better CI, and target coverage (p < 0.01) than TD and hybrid plans in all patient plan evaluations. However, TD plans D2%, D98%, and D50% doses were better than TH and hybrid plans. The HI values were similar between the three plans. Significant reductions in bladder and rectum V50%, V35%, and V25% doses (p < 0.001) were observed with hybrid plans compared to TH and TD. Penile bulb V95% and bowel V5% doses were better in the hybrid plans. Left and right femoral head V5% doses were higher in the hybrid plan compared to others (p < 0.001). Conclusion Concurrently hybrid TH/TD RT plan can be a good option to reduce the doses of the rectum and bladder in the RT of LPC.