Insulin degludec improves long-term glycaemic control similarly to insulin glargine but with fewer hypoglycaemic episodes in patients with advanced type 2 diabetes on basal-bolus insulin therapy

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Hollander P., King A. B., Del Prato S., Sreenan S., BALCI M. K., Munoz-Torres M., ...Daha Fazla

DIABETES OBESITY & METABOLISM, cilt.17, sa.2, ss.202-206, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/dom.12411
  • Dergi Adı: DIABETES OBESITY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.202-206
  • Anahtar Kelimeler: glycaemic control, hypoglycaemia, insulin degludec, type 2 diabetes, VARIABILITY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The aim of the present study was to compare the long-term safety and efficacy of insulin degludec with those of insulin glargine in patients with advanced type 2 diabetes (T2D) over 78weeks (the 52-week main trial and a 26-week extension). Patients were randomized to once-daily insulin degludec or insulin glargine, with mealtime insulin aspart +/- metformin +/- pioglitazone, and titrated to pre-breakfast plasma glucose values of 3.9-4.9mmol/l (70-88mg/dl). After 78weeks, the overall rate of hypoglycaemia was 24% lower (p=0.011) and the rate of nocturnal hypoglycaemia was 31% lower (p=0.016) with insulin degludec in the extension trial set, while both groups of patients achieved similar glycaemic control. Rates of adverse events and total insulin doses were similar for both groups in the safety analysis set. During 18months of treatment, insulin degludec+mealtime insulin aspart +/- oral antidiabetic drugs in patients with T2D improves glycaemic control similarly, but confers lower risks of overall and nocturnal hypoglycaemia than with insulin glargine treatment.