Catecholestradiol Activation of Adrenergic Receptors Induces Endometrial Cell Survival via p38 MAPK Signaling

Sprague R., Kim J. W., KIRIMLIOĞLU E., Guo X., Gunay N., Guzeloglu-Kayisli O., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.106, no.2, pp.337-350, 2021 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 106 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1210/clinem/dgaa866
  • Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, Gender Studies Database, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.337-350
  • Keywords: endometriosis, catecholestradiol, endometrial cell survival, p38 MAPK, adrenergic receptor
  • Akdeniz University Affiliated: Yes

Abstract

Context: Enhanced levels of catecholestradiols, 2-hydroxyestradiol (2-OHE2) or 4-hydroxyestradiol (4-OHE2), are reported in endometriosis. During gestation, catecholestradiol activation of adrenergic receptors (AR) elevates estrogen receptor (ER)-independent proliferation of uterine arterial endothelial cells.