Effect of cadmium on antioxidant status in alloxane-induced diabetic rats


Gumuslu S., Yargicoglu P., Agar A., Edremitlioglu M., Alıcıgüzel Y.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.57, no.2, pp.105-114, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 2
  • Publication Date: 1997
  • Doi Number: 10.1007/bf02778193
  • Journal Name: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.105-114
  • Keywords: cadmium, selenium, vitamin E, ceruloplasmin, rat, GLUTATHIONE-PEROXIDASE ACTIVITIES, RED-CELL LIPIDS, VITAMIN-E, SELENIUM SUPPLEMENTATION, BIOCHEMICAL PARAMETERS, ASCORBIC-ACID, GROWING-RATS, SERUM, PLASMA, BLOOD
  • Akdeniz University Affiliated: Yes

Abstract

Fifty-two healthy Swiss Male Albino rats aged two mo were used in this study. They were divided into four groups: control (C), diabetic (D), cadmium (Cd), and diabetic + Cd (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 ip (2 mg/kg/wk). At the end of the 2-mo experimental period, thiobarbituric acid reactive substances (TEARS), plasma and erythrocyte selenium (Se), plasma ceruloplasmin (Cp), and vitamin E (vit E) were determined in four groups of rats.