Magic ferritin: A novel chemotherapeutic encapsulation bullet

Simsek E., Kilic M. A.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, cilt.293, sa.1, ss.509-513, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 293 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jmmm.2005.01.066
  • Dergi Adı: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.509-513
  • Anahtar Kelimeler: apoferritin, doxorubicin, encapsulation, ferritin, chemotherapy, DRUG-DELIVERY, LIPOSOMES, RECEPTOR, SERUM
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin-HCl gives rise to a solution containing five doxorubicin-HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity. (c) 2005 Published by Elsevier B.V.