Effect of intrathecal FK506 administration on intraorbital optic nerve crush: an ultrastructural study

SARIKCIOĞLU L., DEMİR N., AKAR Y., Demirtop A.

CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, cilt.44, sa.4, ss.427-430, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3129/i09-071
  • Dergi Adı: CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.427-430
  • Anahtar Kelimeler: intrathecal administration, FK506, crush injury, optic nerve, protection, RETINAL GANGLION-CELLS, RAT SCIATIC-NERVE, AXONAL REGENERATION, TACROLIMUS FK506, ADULT-RAT, FK-506, UVEITIS, INJURY, STREPTOMYCES, CYCLOSPORINE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Trauma to the optic nerve caused by fractures of the midface and (or) skull base has been simulated by an optic nerve crush injury model. Because the intraorbital segment of the optic nerve is surrounded by subarachnoidal cerebrospinal fluid and dura mater, we aimed to study the influence of intrathecal tacrolimus (FK506) administration after optic nerve crush injury and to determine its role in optic nerve protection or sparing after injury.