A study detection of the ROS1 gene fusion by FISH and ROS1 protein expression by IHC methods in patients with ovarian malignant or borderline serous tumors


Aydin H. A., Pestereli E., ÖZCAN M., Bayramoglu Z., ERDOĞAN G., ŞİMŞEK T.

PATHOLOGY RESEARCH AND PRACTICE, vol.214, no.11, pp.1868-1872, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 214 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.1016/j.prp.2018.09.016
  • Journal Name: PATHOLOGY RESEARCH AND PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1868-1872
  • Keywords: FISH, Immunohistochemistry, ROS1, Ovarian serous tumors, LUNG-CANCER, ABRIDGED-REPUBLICATION, STAGING CLASSIFICATION, TYROSINE KINASE, FALLOPIAN-TUBE, PERITONEUM
  • Akdeniz University Affiliated: Yes

Abstract

Objective: ROS1 is an orphan receptor protein tyrosine kinase which is supposed to undergo genetic rearrangement in carcinogenesis. In the current study, we aimed to investigate the frequency and clinicopathologic features associated with ROS1 gene fusion and ROS1 protein expression in patients with ovarian serous carcinoma or serous borderline tumors.