Comparison of intraperitoneal antithrombin III and heparin in experimental peritonitis

AKMAN S., Koyun M., Gelen T., COŞKUN M.

PEDIATRIC NEPHROLOGY, vol.23, no.8, pp.1327-1330, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1007/s00467-008-0829-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1327-1330
  • Keywords: peritonitis, AT-III, heparin, antifibrotic effect, ANIMAL-MODEL, DIALYSIS, ULTRAFILTRATION, COAGULATION
  • Akdeniz University Affiliated: Yes


The antifibrotic effect of heparin, an anticoagulant used routinely in the treatment of peritonitis, is unknown, whereas antithrombin III (AT-III) has both anticoagulant and anti-inflammatory actions. The aim of this study was to compare the antifibrotic and anti- inflammatory effects of ATIII and heparin in rats with experimentally developed peritonitis while on peritoneal dialysis (PD). Sixty- fourWistar albino rats (in four groups of 16) were used in the study. Group 1 received PD solution only, group 2 had experimentally developed peritonitis in addition to PD solution; group 3 received heparin intraperitoneally for 3 days, in addition to group 2; and group 4 received AT- III intraperitoneally for 3 days, in addition to group 2. Plasma and dialysate levels of tissue- plasminogen activator were similar in heparin and ATIII groups on both day 3 and day 14. The inflammation scores of heparin and AT- III groups were also similar in both early and late phases. The fibrosis score of the AT- III group was low compared with both peritonitis and heparin groups in the early phase (p= 0.03), though it was similar in the late phase. The effects of AT-III are comparable with that of heparin in PD peritonitis in rats with experimentally developed peritonitis while on PD.