LARVICIDAL ACTIVITY OF LICHEN SECONDARY METABOLITES ATRANORIN AND (-)-USNIC ACID AGAINST THE YELLOW FEVER MOSQUITO Aedes aegypti

KOÇ S., Tufan-Cetin O., Candan M., Turk A., ÇETİN H.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.30, sa.11, ss.11938-11941, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 11
  • Basım Tarihi: 2021
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.11938-11941
  • Anahtar Kelimeler: Aedes aegypti, Atranorin, Larvicidal, Mosquito, Usnic acid
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aedes aegypti L. (Diptera: Culicidae) is one of the most dangerous mosquito species in the world. This species transmits pathogens of many diseases that cause more than ten thousand human deaths to occur annually worldwide. For the control ofAe. aegypti, different types of insecticide groups are widely used but this mosquito developed resistance to many of these insecticides. Lichens are special organisms that include fungi with algae and/or cyanobacteria. They can produce various kinds of secondary metabolites that have biological activities on different pests. Of these metabolites; atranorin and usnic acid are the most known and common metabolites extracted from many lichen species. In this research, it was aimed to investigate the toxic effects of (-)-usnic acid and atranorin on larvae of Ae. aegypti. Aedes aegypti late second and early third instar larvae were used in toxicity assays. Stock solutions of atranorin and (-)-usnic acid were prepared by dissolving of metabolite in acetone. Ten larvae ofAe. aegypti were released to the test solution and the mortalities were recorded at 24 h intervals during 120 h and the percentage mortality rates were obtained from the average of four replicates. Lethal concentrations were calculated using probit analysis. According to results. both metabolites caused high mortalities and the median lethal concentrations (LC50) of the atranorin and usnic acid were determined as 3.3 ppm and 3.8 ppm, respectively at 120 h. Atranorin, at 10 ppm concentration, caused 100% mortality while usnic acid at 10 ppm concentration caused 61.3%. Lichens produce many secondary metabolites and we suggested that these metabolites could be used for development of new mosquicidal agents.