Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage.

Goksu E. T., Dogan O., Ulker P., Tanrıover G., Konuk E., Dilmac S., ...More

Acta neurochirurgica, vol.158, no.9, pp.1721-30, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 158 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.1007/s00701-016-2866-5
  • Journal Name: Acta neurochirurgica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1721-30
  • Keywords: Subarachnoid hemorrhage, Pentoxifylline, Early brain injury, Inflammation, Apoptosis, FOCAL CEREBRAL-ISCHEMIA, NECROSIS-FACTOR-ALPHA, CEREBROSPINAL-FLUID, BLOOD-FLOW, APOPTOSIS, EDEMA, DEFORMABILITY, MACROPHAGES, VASOSPASM
  • Akdeniz University Affiliated: Yes

Abstract

Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease frequently caused by ruptured aneurysms. Early brain injury (EBI) is the primary cause of morbidity and mortality in patients diagnosed with SAH and is associated with increased intracranial pressure, decreased cerebral blood flow and cerebral ischemia. Pentoxifylline (PTX) is a methylxanthine derivative clinically proven to improve perfusion in the peripheral microcirculation and has been shown to have neuroprotective effects in brain trauma and global cerebral ischemia in experimental animal models. This study aimed to determine the effect of PTX in experimental SAH, which has not been investigated yet.